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Measles immunity and immunosuppression.
- Source :
-
Current opinion in virology [Curr Opin Virol] 2021 Feb; Vol. 46, pp. 9-14. Date of Electronic Publication: 2020 Sep 04. - Publication Year :
- 2021
-
Abstract
- Effects of measles on the immune system are only partially understood. Lymphoid tissue is a primary site of measles virus (MeV) replication where CD150 is the receptor for infection of both B and T cells. Lymphocyte depletion occurs during the acute phase of infection, but initiation of the adaptive immune response leads to extensive lymphocyte proliferation, production of MeV-specific antibody and T cells, the rash and clearance of infectious virus. Viral RNA persists in lymphoid tissue accompanied by ongoing germinal center proliferation, production of antibody-secreting cells, functionally distinct populations of T cells and antibody avidity maturation to establish life-long immunity. However, at the same time diversity of pre-existing antibodies and numbers of memory and naive B cells are reduced and susceptibility to other infections is increased.<br /> (Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-6265
- Volume :
- 46
- Database :
- MEDLINE
- Journal :
- Current opinion in virology
- Publication Type :
- Academic Journal
- Accession number :
- 32891958
- Full Text :
- https://doi.org/10.1016/j.coviro.2020.08.002