Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells.

Authors :: Gudkova OI
Demchenko AG
Shvets AV
Kuryakov VN
Sedyakina NE
Lyundup AV
Feldman NB
Gromovykh TI
Lutsenko SV
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Aug; Vol. 169 (4), pp. 508-511. Date of Electronic Publication: 2020 Sep 10.
Publication Year :: 2020
Abstract: A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with a low concentration of agaricinic acid stimulated and with high concentration - suppressed metabolic activity and viability of hepatoma cells. The EC <subscript>50</subscript> for the stimulating effect was 32.8 μg/ml, and the IC <subscript>50</subscript> =602.1 mg/ml. The preparation of agaricinic acid nanoparticles can be used in medicine as a potential antitumor agent.

Subjects :: Alkanes isolation & purification
Antineoplastic Agents isolation & purification
Cell Survival drug effects
Dose-Response Relationship, Drug
Fruiting Bodies, Fungal chemistry
Hep G2 Cells
Humans
Particle Size
Tricarboxylic Acids isolation & purification
Alkanes pharmacology
Antineoplastic Agents pharmacology
Coriolaceae chemistry
Nanoparticles chemistry
Tricarboxylic Acids pharmacology

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