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Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa.
- Source :
-
Nature reviews. Microbiology [Nat Rev Microbiol] 2020 Dec; Vol. 18 (12), pp. 690-704. Date of Electronic Publication: 2020 Sep 10. - Publication Year :
- 2020
-
Abstract
- The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a global pandemic, prompting unprecedented efforts to contain the virus. Many developed countries have implemented widespread testing and have rapidly mobilized research programmes to develop vaccines and therapeutics. However, these approaches may be impractical in Africa, where the infrastructure for testing is poorly developed and owing to the limited manufacturing capacity to produce pharmaceuticals. Furthermore, a large burden of HIV-1 and tuberculosis in Africa could exacerbate the severity of infection and may affect vaccine immunogenicity. This Review discusses global efforts to develop diagnostics, therapeutics and vaccines, with these considerations in mind. We also highlight vaccine and diagnostic production platforms that are being developed in Africa and that could be translated into clinical development through appropriate partnerships for manufacture.<br /> (© 2020. Springer Nature Limited.)
- Subjects :
- Africa epidemiology
COVID-19 epidemiology
Clinical Decision-Making
Coinfection
Disease Management
Disease Susceptibility
Humans
Population Surveillance
Vaccination
Vaccinology methods
Viral Vaccines administration & dosage
Viral Vaccines immunology
COVID-19 diagnosis
COVID-19 prevention & control
COVID-19 therapy
SARS-CoV-2 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1740-1534
- Volume :
- 18
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature reviews. Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 32913297
- Full Text :
- https://doi.org/10.1038/s41579-020-00441-3