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Effects of chitosan oligosaccharides on intestinal oxidative stress and inflammation response in heat stressed rats.
- Source :
-
Experimental animals [Exp Anim] 2021 Feb 06; Vol. 70 (1), pp. 45-53. Date of Electronic Publication: 2020 Sep 11. - Publication Year :
- 2021
-
Abstract
- This study was to verify the effects of chitosan oligosaccharides (COS) on intestinal integrity, oxidative status, and inflammatory response in a heat-stressed rat model. A total of 24 male Sprague Dawley rats were randomly divided into 3 treatment: CON, the control group; HS, the heat stress group; HSC, the heat stress group with 200 mg/kg COS. Rats in the HS and HSC group exposed to a cyclical heat stress for 7 consecutive days. The CON and HS group provided basal diet, and the HSC group provided the same diet with 200 mg/kg COS. Compared with the HS group, rats in the HSC group had lower serum diamine oxidase and D-lactate acid level, higher villus height of jejunum and ileum, lower malondialdehyde (MDA) content in duodenum, jejunum, and ileum mucosa, higher glutathione peroxidase (GSH-Px), catalase (CAT) and total antioxidant capacity (T-AOC) activity in duodenum mucosa, higher T-AOC activity in jejunum mucosa, and higher glutathione (GSH) level in ileum mucosa. Compared with the HS group, rats in the HSC group had higher interleukin-10 (IL-10) level, but lower tumor necrosis factor-α (TNF-α) level in duodenum, jejunum, and ileum mucosa. These results indicated that COS may alleviate intestinal damage under heat stress condition, probably by modulating intestinal inflammatory response and oxidative status.
- Subjects :
- Administration, Oral
Animals
Antioxidants metabolism
Catalase metabolism
Chitosan administration & dosage
Glutathione metabolism
Glutathione Peroxidase metabolism
Inflammation
Interleukin-10 metabolism
Intestinal Mucosa pathology
Male
Malondialdehyde metabolism
Models, Animal
Oligosaccharides administration & dosage
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha metabolism
Rats
Chitosan pharmacology
Heat-Shock Response drug effects
Intestinal Mucosa metabolism
Oligosaccharides pharmacology
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1881-7122
- Volume :
- 70
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Experimental animals
- Publication Type :
- Academic Journal
- Accession number :
- 32921697
- Full Text :
- https://doi.org/10.1538/expanim.20-0085