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Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension.
- Source :
-
International journal of medical sciences [Int J Med Sci] 2020 Aug 01; Vol. 17 (14), pp. 2180-2186. Date of Electronic Publication: 2020 Aug 01 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Background: The essential hypertension (EH) pathophysiology remains poorly understood. Many studies indicate that reduced leukocyte telomere length (LTL) is involved in the EH pathogenesis, however, the direct analysis of arterial telomere length (ATL) from EH patients and normotensive individuals did not show a difference. To address these discrepant observations between LTL and ATL, we performed comprehensive analyses of LTL, telomerase gene expression and their genetic variants in healthy normotensive controls and EH patients. Methods: Sex-matched 206 EH patients and equal numbers of healthy controls were recruited. LTL, and the expression of two key telomerase components, telomerase reverse transcriptase (TERT) and internal RNA template (TERC) were determined using qPCR. Genetic variants of rs2736100 at the TERT and rs12696304 at the TERC loci were determined using TaqMan genotyping kits. Results: LTL was significantly shorter in EH patients than in their normotensive controls (0.96 ± 0.52 vs 1.19 ± 0.58, P = 0.001). Moreover, TERT and TERC expression in patients' leukocytes were substantially lower compare to that in healthy controls (TERT, 0.98 ± 0.98 vs 1.76 ± 1.75, P = 0.003; TERC, 1.26 ± 1.62 vs 4.69 ± 3.61, P < 0.001). However, there were no differences in the genetic variants of rs2736100 and rs12696304 between patient and control groups. Conclusions: EH patients have significantly shorter LTL, which may result from defective TERT and TERC expression in leukocytes. Collectively, lower telomerase expression contributes to shorter LTL observed in EH patients, and telomerase activators may be considered for EH therapy.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)
- Subjects :
- Aged
Alleles
Antihypertensive Agents pharmacology
Antihypertensive Agents therapeutic use
Blood Pressure Determination
Case-Control Studies
Enzyme Activators pharmacology
Enzyme Activators therapeutic use
Essential Hypertension diagnosis
Essential Hypertension drug therapy
Female
Gene Expression Profiling
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
RNA metabolism
Telomerase metabolism
Telomere Homeostasis drug effects
Essential Hypertension genetics
RNA genetics
Telomerase genetics
Telomere metabolism
Telomere Homeostasis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1449-1907
- Volume :
- 17
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- International journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32922179
- Full Text :
- https://doi.org/10.7150/ijms.48456