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Emerging HxNy Influenza A Viruses.
- Source :
-
Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2022 Feb 01; Vol. 12 (2). Date of Electronic Publication: 2022 Feb 01. - Publication Year :
- 2022
-
Abstract
- The continuous emergence and reemergence of diverse subtypes of influenza A viruses, which are known as "HxNy" and are mediated through the reassortment of viral genomes, account for seasonal epidemics, occasional pandemics, and zoonotic outbreaks. We summarize and discuss the characteristics of historic human pandemic HxNy viruses and diverse subtypes of HxNy among wild birds, mammals, and live poultry markets. In addition, we summarize the key molecular features of emerging infectious HxNy influenza viruses from the perspectives of the receptor binding of Hx, the inhibitor-binding specificities and drug-resistance features of Ny, and the matching of the gene segments. Our work enhances our understanding of the potential threats of novel reassortant influenza viruses to public health and provides recommendations for effective prevention, control, and research of this pathogen.<br /> (Copyright © 2022 Cold Spring Harbor Laboratory Press; all rights reserved.)
Details
- Language :
- English
- ISSN :
- 2157-1422
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor perspectives in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32928891
- Full Text :
- https://doi.org/10.1101/cshperspect.a038406