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[Non-aspergillus molds infection after allogeneic stem cell transplantation: clinical analysis of 24 cases and outcomes].

Authors :
Zhao C
Wang Q
Wang Y
Yan CH
Xu LP
Zhang XH
Liu KY
Huang XJ
Sun YQ
Source :
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2020 Aug 14; Vol. 41 (8), pp. 624-629.
Publication Year :
2020

Abstract

Objective: To analyze the clinical characteristics and outcomes of non-aspergillus molds infection (NAMI) patients who underwent allogeneic stem cell transplantation. Methods: Total 24 patients diagnosed as proven or probable non-aspergillus molds infection after allo-HSCT at the Peking University Institute of Hematology from January 2010 to December 2016 were retrospectively reviewed. Results: Among the 24 non-aspergillus molds infection patients, 22 (91.6%) underwent haploidentical stem cell transplantation, while 1 (4.2%) underwent matched-sibling donor transplantation, and 1 (4.2%) underwent HLA-matched unrelated donor transplantation. Ten (41.7%) patients were diagnosed as proven NAMI, and 14 (58.3%) were probable NAMI. The median time to NAMI diagnosis was 188 (2-856) d after transplantation. Five (20.8%) patients had Mucorales infection, 14 (58.3%) Rhizopus infection, 3 (12.5%) had Absidia orchidis infection, and 2 (8.3%) had Scedosporium apiospermum infection. The response rate at was 38.9% (7/18) in 18 patients who adjusted antifungal therapy based on the etiology. After a median 229 (2-2280) days follow-up after diagnosis, the 2-year overall survival was (24.0±14.5) %. Conclusion: The major pathogen of NAMI after allo-HSCT was Rhizopus, and the mortality of NAMI after allo-HSCT was very high due to lack of early effective therapy.

Details

Language :
Chinese
ISSN :
0253-2727
Volume :
41
Issue :
8
Database :
MEDLINE
Journal :
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Publication Type :
Academic Journal
Accession number :
32942814
Full Text :
https://doi.org/10.3760/cma.j.issn.0253-2727.2020.08.002