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Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out.
- Source :
-
Scientific reports [Sci Rep] 2020 Sep 22; Vol. 10 (1), pp. 15442. Date of Electronic Publication: 2020 Sep 22. - Publication Year :
- 2020
-
Abstract
- Tuberculosis (TB) misdiagnosis remains a public health concern, especially among people living with HIV (PLHIV), given the high mortality associated with missed TB diagnoses. The main objective of this study was to describe the all-cause mortality, TB incidence rates and their associated risk factors in a cohort of PLHIV with presumptive TB in whom TB was initially ruled out. We retrospectively followed a cohort of PLHIV with presumptive TB over a 2 year-period in a rural district in Southern Mozambique. During the study period 382 PLHIV were followed-up. Mortality rate was 6.8/100 person-years (PYs) (95% CI 5.2-9.2) and TB incidence rate was 5.4/100 PYs (95% CI 3.9-7.5). Thirty-six percent of deaths and 43% of TB incident cases occurred in the first 12 months of the follow up. Mortality and TB incidence rates in the 2-year period after TB was initially ruled out was very high. The TB diagnostic work-up and linkage to HIV care should be strengthened to decrease TB burden and all-cause mortality among PLHIV with presumptive TB.
- Subjects :
- Adult
Coinfection epidemiology
Coinfection virology
Female
HIV Infections epidemiology
HIV Infections virology
Humans
Incidence
Male
Middle Aged
Mozambique epidemiology
Prognosis
Retrospective Studies
Risk Factors
Survival Rate
Tuberculosis epidemiology
Tuberculosis virology
Coinfection mortality
HIV isolation & purification
HIV Infections mortality
Mycobacterium tuberculosis isolation & purification
Tuberculosis mortality
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32963296
- Full Text :
- https://doi.org/10.1038/s41598-020-71784-3