The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

Authors :: Sun HB
Zhang YM
Huang LG
Lai QN
Mo Q
Ye XZ
Wang T
Zhu ZZ
Lv XL
Luo YJ
Gao SD
Xu JS
Zhu HH
Li T
Wang ZK
Source :: PloS one [PLoS One] 2020 Sep 25; Vol. 15 (9), pp. e0239532. Date of Electronic Publication: 2020 Sep 25 (Print Publication: 2020).
Publication Year :: 2020
Abstract: To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.<br />Competing Interests: The authors have declared that no competing interests exist.

Full Text Access

Tools