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Toxicological assessment and developmental abnormalities induced by butylparaben and ethylparaben exposure in zebrafish early-life stages.
- Source :
-
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2020 Nov; Vol. 80, pp. 103504. Date of Electronic Publication: 2020 Sep 24. - Publication Year :
- 2020
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Abstract
- Toxicological effects of butylparaben (BuP) and ethylparaben (EtP) on zebrafish (Danio rerio) early-life stages are not well established. The present study evaluated, using zebrafish embryos and larvae, the toxicity of BuP and EtP through benchmark dose (BMD) approach. BuP was more toxic than EtP to zebrafish larvae. In fact, Lethal Concentration 50 (LC50) values at 96 h post-fertilization (hpf) for BuP and EtP were 2.34 mg/L and 20.86 mg/L, respectively. Indeed, BMD confidence interval (lower bound (BMDL) - upper bound (BMDU) was 0.91-1.92 mg/L for BuP and 10.8-17.4 mg/L for EtP. Zebrafish embryos exposed to 1 mg/L, 2.5 mg/L of BuP and 5 mg/L, 10 mg/L, 20 mg/L, 30 mg/L of EtP showed several developmental abnormalities and teratological effects compared to negative control. Exposed zebrafish developed reduced heartbeat, reduction in blood circulation, blood stasis, pericardial edema, deformed notochord and misshaped yolk sac. Embryos exposed to the highest concentrations of the chemicals (2.5 mg/L of BuP, 10 mg/L, 20 mg/L and 30 mg/L of EtP) showed the developmental abnormalities at 48 hpf while those treated with 1 mg/L of BuP and 10 mg/L of EtP reported behavioral changes at 72 hpf, including trembling of head, pectoral fins and spinal cord. This research identified the lethal and sublethal effects of BuP and EtP in zebrafish early-life stages and could be helpful to elucidate the developmental pathways of toxicity of parabens.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Behavior, Animal drug effects
Blood Circulation drug effects
Edema chemically induced
Embryo, Nonmammalian abnormalities
Embryo, Nonmammalian drug effects
Female
Hemostasis drug effects
Larva drug effects
Lethal Dose 50
Male
Notochord abnormalities
Notochord drug effects
Pericardium drug effects
Pericardium pathology
Yolk Sac abnormalities
Yolk Sac drug effects
Parabens toxicity
Water Pollutants, Chemical toxicity
Zebrafish abnormalities
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7077
- Volume :
- 80
- Database :
- MEDLINE
- Journal :
- Environmental toxicology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32980526
- Full Text :
- https://doi.org/10.1016/j.etap.2020.103504