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Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture.

Authors :
Mirakhur RK
Dundee JW
Clarke RS
Source :
British journal of anaesthesia [Br J Anaesth] 1977 Aug; Vol. 49 (8), pp. 825-9.
Publication Year :
1977

Abstract

Glycopyrrolate, a new anticholinergic agent, was evaluated and compared with atropine. Glycopyrrolate 0.2 mg to neostigmine 1.0 mg was found to be safe and effective. The heart rates remained more stable with glycopyrrolate, and the frequency of arrhythmia, which was both transient and of no consequence, was similar in the two groups. The antisialogogue action of glycopyrrolate was superior to that of atropine.

Details

Language :
English
ISSN :
0007-0912
Volume :
49
Issue :
8
Database :
MEDLINE
Journal :
British journal of anaesthesia
Publication Type :
Academic Journal
Accession number :
329848
Full Text :
https://doi.org/10.1093/bja/49.8.825