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Manniindole, an indole derivative from the roots of Anonidium mannii and combined antischistosomal and enzymatic activities.

Manniindole, an indole derivative from the roots of Anonidium mannii and combined antischistosomal and enzymatic activities.

Authors :
Toussi Matchi JL
Tchamo Noungoue D
Kuhn I
Boissier J
Tchouankeu JC
Nothisen M
Chaubet G
Garnier D
Ursuegui S
Ngouela SA
Wagner A
Source :
Natural product research [Nat Prod Res] 2021 Dec; Vol. 35 (24), pp. 5665-5673. Date of Electronic Publication: 2020 Sep 28.
Publication Year :
2021

Abstract

A new alkaloid, manniindole 1 , together with four known compounds: aristolactam AII 2 , aristolactam BII 3 , piperolactam D 4 and polycarpol 5 were isolated from the crude extract EtOH-H <subscript>2</subscript> O (8:2) of the roots of Anonidium mannii by chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison of their spectral data with those reported in the literature. For the first time, the crude extract and those isolated compounds were evaluated for their anti-schistosomal activity against Schistosoma mansoni and for cytotoxicity activity against Huh7 and A549 cells. Furthermore, they were also tested in vitro on the recent characterized Schistosoma mansoni NAD <superscript>+</superscript> catabolizing enzyme ( Sm NACE) for their impact on this enzyme which is localized on the outer surface of the adult parasite. Compound 2 displayed quite good worm killing capability, while 4 showed significant inhibition of Sm NACE.

Details

Language :
English
ISSN :
1478-6427
Volume :
35
Issue :
24
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
32985247
Full Text :
https://doi.org/10.1080/14786419.2020.1824227