Back to Search Start Over

Clinical Efficacy of Tumor Treating Fields for Newly Diagnosed Glioblastoma.

Authors :
Liu Y
Strawderman MS
Warren KT
Richardson M
Serventi JN
Mohile NA
Milano MT
Walter KA
Source :
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5801-5806.
Publication Year :
2020

Abstract

Background/aim: Whether adding tumor treating fields (TTF) to the Stupp protocol increases survival for glioblastoma (GBM) patients in routine clinical care remains unknown.<br />Patients and Methods: We retrospectively identified adult patients with newly diagnosed GBM (n=104) treated with the Stupp protocol or TTF at our Institution.<br />Results: Thirty-six percent (37/104) of patients received TTF in conjunction with the Stupp protocol and these patients had increased 6-month (p=0.006) and 1-year (p=0.170), but not 2-year survival rates compared to the 67-patients who received Stupp alone. The improvement of survival rate at 6-month was further confirmed by a modified Poisson model (p=0.010). However, we did not observe any improvement in overall survival (OS) with a Cox model.<br />Conclusion: While adding TTF to the Stupp protocol appeared to benefit patients with newly diagnosed GBM, this effect was mild and may be largely due to selection bias.<br /> (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Details

Language :
English
ISSN :
1791-7530
Volume :
40
Issue :
10
Database :
MEDLINE
Journal :
Anticancer research
Publication Type :
Academic Journal
Accession number :
32988908
Full Text :
https://doi.org/10.21873/anticanres.14597