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Clinical Efficacy of Tumor Treating Fields for Newly Diagnosed Glioblastoma.
- Source :
-
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5801-5806. - Publication Year :
- 2020
-
Abstract
- Background/aim: Whether adding tumor treating fields (TTF) to the Stupp protocol increases survival for glioblastoma (GBM) patients in routine clinical care remains unknown.<br />Patients and Methods: We retrospectively identified adult patients with newly diagnosed GBM (n=104) treated with the Stupp protocol or TTF at our Institution.<br />Results: Thirty-six percent (37/104) of patients received TTF in conjunction with the Stupp protocol and these patients had increased 6-month (p=0.006) and 1-year (p=0.170), but not 2-year survival rates compared to the 67-patients who received Stupp alone. The improvement of survival rate at 6-month was further confirmed by a modified Poisson model (p=0.010). However, we did not observe any improvement in overall survival (OS) with a Cox model.<br />Conclusion: While adding TTF to the Stupp protocol appeared to benefit patients with newly diagnosed GBM, this effect was mild and may be largely due to selection bias.<br /> (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Alkylating adverse effects
Brain Neoplasms epidemiology
Brain Neoplasms pathology
Combined Modality Therapy
Dacarbazine administration & dosage
Dacarbazine adverse effects
Disease-Free Survival
Female
Glioblastoma epidemiology
Glioblastoma pathology
Humans
Male
Middle Aged
Survival Rate
Temozolomide administration & dosage
Temozolomide adverse effects
Treatment Outcome
Antineoplastic Agents, Alkylating administration & dosage
Brain Neoplasms drug therapy
Glioblastoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 40
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 32988908
- Full Text :
- https://doi.org/10.21873/anticanres.14597