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Osimertinib induced cardiomyopathy: A case report.
- Source :
-
Medicine [Medicine (Baltimore)] 2020 Sep 25; Vol. 99 (39), pp. e22301. - Publication Year :
- 2020
-
Abstract
- Rationale: Cardiotoxicity related to osimertinib, including cardiac failure, QT prolongation, and atrial fibrillation, has been reported as an extremely rare incidence in patients with advanced non-small cell lung cancer (NSCLC). However, little is known about the occurrence of osimertinib-induced cardiomyopathy.<br />Patient Concerns: A 76-year old woman was treated with afatinib (40 mg/day) as the 1st line treatment due to recurrence after surgical resection for pulmonary adenocarcinoma. However, she experienced recurrence with positive T790 M, and osimertinib (80 mg/day) was administered as the 2nd line therapy.<br />Diagnosis: Four months after osimertinib initiation, she complained of fever and progressive dyspnea, and a diagnostic endomyocardial biopsy confirmed non-specific cardiomyopathy, indicating osimertinib-induced cardiomyopathy.<br />Interventions and Outcomes: She was treated with furosemide, carvedilol, and enalapril, and her cardiac function, her symptoms, and condition improved 3 weeks after the withdrawal of osimertinib.<br />Lessons: Physicians should be alert of the cardiomyopathy-causing potential of osimertinib in advanced NSCLC patients.
- Subjects :
- Acrylamides therapeutic use
Adenocarcinoma of Lung drug therapy
Adrenergic beta-Antagonists therapeutic use
Afatinib therapeutic use
Aged
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Aniline Compounds therapeutic use
Cardiomyopathies drug therapy
Cardiomyopathies physiopathology
Carvedilol therapeutic use
Diuretics therapeutic use
Enalapril therapeutic use
Female
Furosemide therapeutic use
Humans
Lung Neoplasms pathology
Protein Kinase Inhibitors therapeutic use
Recurrence
Treatment Outcome
Withholding Treatment
Acrylamides adverse effects
Aniline Compounds adverse effects
Cardiomyopathies chemically induced
Protein Kinase Inhibitors adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 99
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32991436
- Full Text :
- https://doi.org/10.1097/MD.0000000000022301