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Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism (SPACE) trial: rationale and design.
- Source :
-
Stroke and vascular neurology [Stroke Vasc Neurol] 2020 Sep; Vol. 5 (3), pp. 311-314. Date of Electronic Publication: 2020 Feb 27. - Publication Year :
- 2020
-
Abstract
- Backgrounds: Embolic stroke is one of the main mechanisms of ischaemic stroke. Even if treated with recommended antithrombotic agents, stroke recurrence remains high. The Shuxuetong injection, a purified extract of traditional Chinese medicine widely used for thrombus diseases in clinical practice in China, could be a promising agent to prevent stroke recurrence.<br />Aims: To describe the design of the Shuxuetong injection for prevention of recurrence in acute ischaemic stroke with embolism mechanisms.<br />Design: The Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism (SPACE) trial is a multicentre, randomised, double-blind, placebo-controlled, parallel-group, superiority trial to evaluate the efficacy and safety of Shuxuetong injection in reducing recurrence or silent new ischaemic lesions on patients with acute embolic stroke within 10 days. An estimated 2416 patients with embolic stroke within 72 hours of symptom onset from 80 hospitals will be randomly assigned to one of two groups receiving Shuxuetong injection or placebo injection for 10 days. The primary endpoint is symptomatic or asymptomatic new cerebral infarction within 10 days after randomisation.<br />Conclusion: The SPACE Trial will provide valuable evidence for the efficacy and safety of Shuxuetong injection for the prevention of stroke recurrence in patients with imaging-defined embolic stroke.<br />Clinical Trial Registration: NCT03090113.<br />Competing Interests: Competing interests: The SPACE programme is an investigator-initiated study and mainly funded by the Ministry of Science and Technology of the People’s Republic of China. Mudanjiang Youbo Pharmaceutical Co., Ltd partly funded this programme; however, the company was not involved in the study design, data collection, data cleaning, data analysis, data interpretation and manuscript writing.<br /> (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Adolescent
Adult
Aged
Brain Ischemia diagnosis
China
Double-Blind Method
Drugs, Chinese Herbal adverse effects
Equivalence Trials as Topic
Female
Humans
Injections
Intracranial Embolism diagnosis
Male
Middle Aged
Multicenter Studies as Topic
Recurrence
Stroke diagnosis
Treatment Outcome
Young Adult
Brain Ischemia drug therapy
Drugs, Chinese Herbal administration & dosage
Intracranial Embolism drug therapy
Secondary Prevention
Stroke drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2059-8696
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Stroke and vascular neurology
- Publication Type :
- Academic Journal
- Accession number :
- 32994371
- Full Text :
- https://doi.org/10.1136/svn-2019-000293