M 6 A modification: A mechanism for protecting hematopoietic development in mammals.

N ⁶ -methyladenosine (m ⁶ A) is one of the most common internal modifications in messenger RNA, which is necessary for cell physiological activities. A recent study shows that during mammalian hematopoietic development, loss of m ⁶ A modification leads to the aberrant production of double-stranded RNA, which results in the abnormal activation of innate immune response, and ultimately leads to hematopoietic failure. Accordingly, m ⁶ A modification provide us an attractive direction for us to understand mammalian hematopoietic development and innate immune response.
(© 2020 International Federation for Cell Biology.)