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Bile acid diarrhoea: Current and potential methods of diagnosis.
- Source :
-
Annals of clinical biochemistry [Ann Clin Biochem] 2021 Jan; Vol. 58 (1), pp. 22-28. Date of Electronic Publication: 2020 Oct 28. - Publication Year :
- 2021
-
Abstract
- Chronic diarrhoea is common and mostly due to diarrhoea predominant irritable bowel syndrome. Diarrhoea predominant irritable bowel syndrome affects about 11% of the population; however, up to a third of these patients actually have bile acid diarrhoea. There are, therefore, more than one million sufferers of bile acid diarrhoea in the UK. Bile acid diarrhoea is caused by small bowel malabsorption of bile acids and the increased bile acids in the large intestine cause diarrhoea. Once diagnosed, the treatment of bile acid diarrhoea is simple and effective. Bile acid diarrhoea , however, is often not diagnosed because of a lack of easily available and reliable diagnostic methods. In the United Kingdom, the radiolabelled 23-seleno-25-homotaurocholic acid test is the gold-standard method of diagnosis. 23-seleno-25-homotaurocholic acid test, however, is expensive, inconvenient to the patient, involves radiation exposure and has limited availability. As such, a laboratory biomarker is desirable. This review briefly discusses the pathophysiology and management of bile acid diarrhoea and critically evaluates methods for its diagnosis, including serum 7α-hydroxy-4-cholesten-3-one, faecal bile acid measurement, serum fibroblast growth factor 19, urine-2-propanol, and the <superscript>14</superscript> C-glycocholate breath and stool test.
- Subjects :
- Humans
Taurocholic Acid metabolism
United Kingdom
Cholestenones metabolism
Diarrhea diagnosis
Diarrhea metabolism
Diarrhea pathology
Fibroblast Growth Factors metabolism
Intestine, Small metabolism
Malabsorption Syndromes diagnosis
Malabsorption Syndromes metabolism
Malabsorption Syndromes pathology
Taurocholic Acid analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1758-1001
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32998535
- Full Text :
- https://doi.org/10.1177/0004563220966139