Back to Search
Start Over
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition.
- Source :
-
Nature immunology [Nat Immunol] 2021 Jan; Vol. 22 (1), pp. 74-85. Date of Electronic Publication: 2020 Sep 30. - Publication Year :
- 2021
-
Abstract
- T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines, identification of exact viral T cell epitopes is fundamental. Here we identify and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell epitopes in COVID-19 convalescent and unexposed individuals. SARS-CoV-2-specific peptides enabled detection of post-infectious T cell immunity, even in seronegative convalescent individuals. Cross-reactive SARS-CoV-2 peptides revealed pre-existing T cell responses in 81% of unexposed individuals and validated similarity with common cold coronaviruses, providing a functional basis for heterologous immunity in SARS-CoV-2 infection. Diversity of SARS-CoV-2 T cell responses was associated with mild symptoms of COVID-19, providing evidence that immunity requires recognition of multiple epitopes. Together, the proposed SARS-CoV-2 T cell epitopes enable identification of heterologous and post-infectious T cell immunity and facilitate development of diagnostic, preventive and therapeutic measures for COVID-19.
- Subjects :
- COVID-19 prevention & control
COVID-19 virology
Cross Reactions immunology
HLA-DR Antigens immunology
HLA-DR Antigens metabolism
Histocompatibility Antigens Class I immunology
Histocompatibility Antigens Class I metabolism
Humans
Immunologic Memory immunology
SARS-CoV-2 physiology
T-Lymphocytes metabolism
Viral Vaccines administration & dosage
COVID-19 immunology
Epitopes, T-Lymphocyte immunology
Peptides immunology
SARS-CoV-2 immunology
T-Lymphocytes immunology
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 32999467
- Full Text :
- https://doi.org/10.1038/s41590-020-00808-x