Longisglucinols A-C, Structurally Intriguing Polycyclic Polyprenylated Acylphloroglucinols with Anti-inflammatory Activity from Hypericum longistylum .

Authors :: Zhang N
Shi Z
Xu Q
Sun W
Gu L
Xie S
Guo Y
Duan Y
Zhang K
Qi C
Zhang Y
Source :: Organic letters [Org Lett] 2020 Oct 16; Vol. 22 (20), pp. 7926-7929. Date of Electronic Publication: 2020 Oct 01.
Publication Year :: 2020
Abstract: Longisglucinol A ( 1 ), a polycyclic polyprenylated acylphloroglucinol (PPAP) with a new skeleton, along with two new congeners, longisglucinols B ( 2 ) and C ( 3 ), were isolated from Hypericum longistylum . Compound 1 features an unparalleled 6/6/6/5 fused ring skeleton based on a unique 8-oxa-tetracyclo-[8.3.3.0 <superscript>1,9</superscript> .0 <superscript>3,7</superscript> ]cetane core. Longisglucinol A showed remarkable anti-inflammatory activity by inducing macrophage M2 polarization through the suppression of NF-κB.

Subjects :: Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents isolation & purification
Magnetic Resonance Spectroscopy
Molecular Structure
NF-kappa B chemistry
NF-kappa B metabolism
Anti-Inflammatory Agents pharmacology
Hypericum chemistry
NF-kappa B antagonists & inhibitors

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