Back to Search
Start Over
Progress Toward Cardiac Xenotransplantation.
Progress Toward Cardiac Xenotransplantation.
- Source :
-
Circulation [Circulation] 2020 Oct 06; Vol. 142 (14), pp. 1389-1398. Date of Electronic Publication: 2020 Oct 05. - Publication Year :
- 2020
-
Abstract
- Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.
- Subjects :
- Animals
Heterografts
Humans
Swine
Graft Survival
Heart
Heart Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4539
- Volume :
- 142
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 33017208
- Full Text :
- https://doi.org/10.1161/CIRCULATIONAHA.120.048186