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Progress Toward Cardiac Xenotransplantation.

Progress Toward Cardiac Xenotransplantation.

Authors :
Pierson RN 3rd
Fishman JA
Lewis GD
D'Alessandro DA
Connolly MR
Burdorf L
Madsen JC
Azimzadeh AM
Source :
Circulation [Circulation] 2020 Oct 06; Vol. 142 (14), pp. 1389-1398. Date of Electronic Publication: 2020 Oct 05.
Publication Year :
2020

Abstract

Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.

Details

Language :
English
ISSN :
1524-4539
Volume :
142
Issue :
14
Database :
MEDLINE
Journal :
Circulation
Publication Type :
Academic Journal
Accession number :
33017208
Full Text :
https://doi.org/10.1161/CIRCULATIONAHA.120.048186