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Synaptophysin Positive Glomus Tumor of Trachea Simulating Typical Carcinoid: A Potential trap.
- Source :
-
Head and neck pathology [Head Neck Pathol] 2021 Sep; Vol. 15 (3), pp. 994-998. Date of Electronic Publication: 2020 Oct 06. - Publication Year :
- 2021
-
Abstract
- Glomus tumors (GTs) are uncommon benign tumors, accounting for <2% of all soft tissue tumors and usually occur within the dermis or subcutis of distal extremities. Primary tracheal GT is rare, and to date less than 40 tracheal GTs have been reported. Tracheal GT usually present as a polypoidal mass. They express smooth muscle markers, and are negative for cytokeratin (CK) and neuroendocrine markers on immunohistochemistry (IHC). We here report a case of tracheal GT showing diffuse strong aberrant immunoexpression for synaptophysin, initially construed as carcinoid. Focal synaptophysin expression has been described in few gastric GTs, and a nasal GT. Diligent histomorphological examination and careful selection of IHC panel helps in clinching the diagnosis. Complete resection is the standard treatment of modality.<br /> (© 2020. Springer Science+Business Media, LLC, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1936-0568
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Head and neck pathology
- Publication Type :
- Academic Journal
- Accession number :
- 33025460
- Full Text :
- https://doi.org/10.1007/s12105-020-01230-3