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Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity.
- Source :
-
Clinical and experimental dermatology [Clin Exp Dermatol] 2021 Apr; Vol. 46 (3), pp. 532-540. Date of Electronic Publication: 2021 Jan 02. - Publication Year :
- 2021
-
Abstract
- Background: Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity.<br />Aim: In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity.<br />Methods: In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed.<br />Results: The mean age of disease onset was 26.2 ± 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 ± 8.4 years with a delay in diagnosis of 5.8 ± 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years.<br />Conclusions: Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity.<br /> (© 2020 British Association of Dermatologists.)
- Subjects :
- Acne Vulgaris complications
Adult
Alcohol Drinking adverse effects
Cross-Sectional Studies
Diabetes Complications
Female
Hidradenitis Suppurativa complications
Humans
Male
Obesity complications
Pilonidal Sinus complications
Retrospective Studies
Risk Factors
Severity of Illness Index
Smoking adverse effects
Hidradenitis Suppurativa diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2230
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and experimental dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 33030217
- Full Text :
- https://doi.org/10.1111/ced.14478