How to bridle a neutrophil.

Authors :: Rubio-Ponce A
Hidalgo A
Ballesteros I
Source :: Current opinion in immunology [Curr Opin Immunol] 2021 Feb; Vol. 68, pp. 41-47. Date of Electronic Publication: 2020 Oct 08.
Publication Year :: 2021
Abstract: Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)