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Effects of Salvia miltiorrhiza and Radix astragali on the TGF-β/Smad/Wnt pathway and the pathological process of liver fibrosis in rats.
- Source :
-
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2020 Sep 30; Vol. 66 (6), pp. 46-51. Date of Electronic Publication: 2020 Sep 30. - Publication Year :
- 2020
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Abstract
- Traditional Chinese medicine has made some progress in the study of liver fibrosis, and provides valuable experience for clinical treatment of liver fibrosis. The aim of this study was to investigate the rationality of compatibility use of Salvia miltiorrhiza and Radix astragali on liver fibrosis in rats. For this purpose, the rat model of liver fibrosis was treated with single or different compatibilities of herbals extracts for 4 weeks. Saline and colchicine were set as a negative and positive control, respectively. Liver histopathology, liver function, and expressions of key proteins in the TGF-β/Smad/Wnt pathway were assessed. Results showed that compared with colchicine, herbal extracts showed better ability to reduce deposition of α-SMA and type I collagen, and improve liver function. The effect of R. astragali extracts and 1:1 compound on improving liver fibrosis and liver function was relatively better than other treatment options. The compound groups showed a particularly significant effect on reducing Cyclin D1 expression. It was concluded that the 1:1 compatibility use of S. miltiorrhiza extracts and R. astragali extracts can preferably attenuate liver fibrosis by regulating the expression of TGF-β1 and Cyclin D1.
- Subjects :
- Animals
Astragalus propinquus
Disease Models, Animal
Drugs, Chinese Herbal pharmacology
Liver drug effects
Liver metabolism
Liver pathology
Liver Cirrhosis metabolism
Liver Cirrhosis pathology
Male
Rats
Rats, Sprague-Dawley
Drugs, Chinese Herbal chemistry
Liver Cirrhosis drug therapy
Plant Extracts pharmacology
Salvia miltiorrhiza chemistry
Smad Proteins metabolism
Transforming Growth Factor beta metabolism
Wnt Signaling Pathway drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1165-158X
- Volume :
- 66
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cellular and molecular biology (Noisy-le-Grand, France)
- Publication Type :
- Academic Journal
- Accession number :
- 33040784