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Sarcoma treatment in the era of molecular medicine.

Authors :
Grünewald TG
Alonso M
Avnet S
Banito A
Burdach S
Cidre-Aranaz F
Di Pompo G
Distel M
Dorado-Garcia H
Garcia-Castro J
González-González L
Grigoriadis AE
Kasan M
Koelsche C
Krumbholz M
Lecanda F
Lemma S
Longo DL
Madrigal-Esquivel C
Morales-Molina Á
Musa J
Ohmura S
Ory B
Pereira-Silva M
Perut F
Rodriguez R
Seeling C
Al Shaaili N
Shaabani S
Shiavone K
Sinha S
Tomazou EM
Trautmann M
Vela M
Versleijen-Jonkers YM
Visgauss J
Zalacain M
Schober SJ
Lissat A
English WR
Baldini N
Heymann D
Source :
EMBO molecular medicine [EMBO Mol Med] 2020 Nov 06; Vol. 12 (11), pp. e11131. Date of Electronic Publication: 2020 Oct 13.
Publication Year :
2020

Abstract

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.<br /> (© 2020 The Authors. Published under the terms of the CC BY 4.0 license.)

Details

Language :
English
ISSN :
1757-4684
Volume :
12
Issue :
11
Database :
MEDLINE
Journal :
EMBO molecular medicine
Publication Type :
Academic Journal
Accession number :
33047515
Full Text :
https://doi.org/10.15252/emmm.201911131