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Why PB28 Could Be a Covid 2019 Game Changer?

Authors :
Colabufo NA
Leopoldo M
Ferorelli S
Abate C
Contino M
Perrone MG
Niso M
Perrone R
Berardi F
Source :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Aug 14; Vol. 11 (10), pp. 2048-2050. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).
Publication Year :
2020

Abstract

PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past decade in our research group. A possible mechanism to explain its surprising anti-COVID-19 activity is suggested..<br />Competing Interests: The authors declare no competing financial interest.

Details

Language :
English
ISSN :
1948-5875
Volume :
11
Issue :
10
Database :
MEDLINE
Journal :
ACS medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
33052254
Full Text :
https://doi.org/10.1021/acsmedchemlett.0c00271