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Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 13; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 13. - Publication Year :
- 2020
-
Abstract
- In the last three decades, oligonucleotides have been extensively investigated as probes, molecular ligands and even catalysts within therapeutic and diagnostic applications. The narrow chemical repertoire of natural nucleic acids, however, imposes restrictions on the functional scope of oligonucleotides. Initial efforts to overcome this deficiency in chemical diversity included conservative modifications to the sugar-phosphate backbone or the pendant base groups and resulted in enhanced in vivo performance. More importantly, later work involving other modifications led to the realization of new functional characteristics beyond initial intended therapeutic and diagnostic prospects. These results have inspired the exploration of increasingly exotic chemistries highly divergent from the canonical nucleic acid chemical structure that possess unnatural physiochemical properties. In this review, the authors highlight recent developments in modified oligonucleotides and the thrust towards designing novel nucleic acid-based ligands and catalysts with specifically engineered functions inaccessible to natural oligonucleotides.
- Subjects :
- Animals
Aptamers, Nucleotide pharmacology
Base Pairing
Carbohydrates chemistry
Catalysis
Enzymes metabolism
Humans
Ligands
Oligonucleotides chemistry
Pentoses chemistry
Aptamers, Nucleotide chemistry
Enzymes chemistry
Gene Editing methods
Nucleic Acids chemistry
Oligonucleotides, Antisense chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 25
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 33066073
- Full Text :
- https://doi.org/10.3390/molecules25204659