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[Clinical Characteristics of Patients with Myeloid Sarcoma].

Authors :: He HS
Su GP
Yao JP
Liu SH
Xu YH
Yang YQ
Huang DP
Source :: Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2020 Oct; Vol. 28 (5), pp. 1491-1495.
Publication Year :: 2020
Abstract: Objective: To investigate the clinical characteristics, diagnosis and treatment methods of patients with myeloid sarcoma(MS)． Methods: The clinical data, laboratory examination, clinical pathology and treatment methods of 15 patients with MS treated in the First Affiliated Hospital of Wannan Medical College from June 2012 to January 2020 were retrospectively analyzed.<br />Results: Among the 15 cases of MS, including eight males and seven females, the middle age of patients were 53（19 to 72）. Among the 15 patients with MS, 4 showed solitary MS, while 11 showed secondary MS. Immunohistochemical results showed that MPO <superscript>+</superscript> （12/15）、CD68 <superscript>+</superscript> （3/6）、Lys <superscript>+</superscript> （3/3）、CD34 <superscript>+</superscript> （6/14）、TdT <superscript>+</superscript> （0/9）、CD43 <superscript>+</superscript> （13/13）、CD117 <superscript>+</superscript> （6/10）、CD15 <superscript>+</superscript> （7/10）、CD3 <superscript>+</superscript> （1/15）、CD20 <superscript>+</superscript> （0/15）. 6 of 13 patients were survival till follow-up date．The median overall survival (OS) time was 16 months (1-88 months)．Conclusion: Myeloid sarcoma is rare and often secondary from acute myeloid leukemia(AML) and chronic myeogenous leukemia(CML). Isolated MS can easily be misdiagnosed as lymphoma. Treatment response should be evaluated in combination with bone marrow examination, PET/CT and other imagines．Systematic chemotherapy and hematopoietic stem cell transplantation are the main method to treat MS.