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Long-term outcomes following maximal safe resection in a contemporary series of childhood craniopharyngiomas.

Authors :
Sarkar S
Chacko SR
Korula S
Simon A
Mathai S
Chacko G
Chacko AG
Source :
Acta neurochirurgica [Acta Neurochir (Wien)] 2021 Feb; Vol. 163 (2), pp. 499-509. Date of Electronic Publication: 2020 Oct 19.
Publication Year :
2021

Abstract

Background: The optimal management of pediatric craniopharyngiomas remains controversial. This study aimed to characterize long-term outcomes in a contemporary cohort of children undergoing surgery for craniopharyngiomas.<br />Methods: This was a retrospective review of 37 consecutive children who underwent surgery for craniopharyngioma with a median follow-up duration of 79 months (range 5-127 months). Patients were stratified by extent of resection (EOR) and need for adjuvant radiation therapy (RT). Imaging studies were reviewed to grade extent of hypothalamic involvement. Data on functional outcomes, pituitary function, and obesity were analyzed.<br />Results: Gross total resection was achieved in 16 patients (43.2%), near total resection in six patients (16.2%), and subtotal resection (STR) in 15 patients (40.5%). The recurrence-free survival rate was 81.1% and 70.3% at 5- and 10-year follow-up, respectively. Survival analysis showed superior disease control in patients undergoing STR + RT (p = 0.008). Functional outcomes were independent of EOR, postoperative RT or recurrence. Diabetes insipidus was present in 75% and 44.4% of patients required >2 hormone replacements at last follow-up. Obesity was present in 36.1% patients after treatment, and was associated with preoperative obesity (p = 0.019), preoperative hypothalamic involvement (p = 0.047) and STR + RT (p = 0.011).<br />Conclusions: Gross or near total resection may be achieved safely in almost 60% of cases; however, radical surgery does not eliminate the risk of recurrence. Over long-term follow-up, STR + RT offers the best disease control rates. Patients with preoperative hypothalamic involvement, obesity, and those with tumors not amenable to radical resection are at risk for developing obesity on long-term follow-up.

Details

Language :
English
ISSN :
0942-0940
Volume :
163
Issue :
2
Database :
MEDLINE
Journal :
Acta neurochirurgica
Publication Type :
Academic Journal
Accession number :
33078364
Full Text :
https://doi.org/10.1007/s00701-020-04591-4