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Catalytic trifluoromethylation of iodoarenes by use of 2-trifluoromethylated benzimidazoline as trifluoromethylating reagent.
- Source :
-
Beilstein journal of organic chemistry [Beilstein J Org Chem] 2020 Sep 30; Vol. 16, pp. 2442-2447. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- The trifluoromethylation of iodoarenes was accomplished by use of a 2-trifluoromethylbenzimidazoline derivative as the trifluoromethylating reagent and a catalytic amount of Cu(I) in the presence of 2,2'-bipyridyl as the ligand. Through a mechanistic study, we found that the oxidative addition of the iodoarene to the Cu(I)-CF <subscript>3</subscript> species is the rate-determining step.<br /> (Copyright © 2020, Uchikura et al.; licensee Beilstein-Institut.)
Details
- Language :
- English
- ISSN :
- 1860-5397
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- Beilstein journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33082878
- Full Text :
- https://doi.org/10.3762/bjoc.16.198