Back to Search
Start Over
An injectable self-healing anesthetic glycolipid-based oleogel with antibiofilm and diabetic wound skin repair properties.
- Source :
-
Scientific reports [Sci Rep] 2020 Oct 22; Vol. 10 (1), pp. 18017. Date of Electronic Publication: 2020 Oct 22. - Publication Year :
- 2020
-
Abstract
- Globally, wound infections are considered as one of the major healthcare problems owing to the delayed healing process in diabetic patients and microbial contamination. Thus, the development of advanced materials for wound skin repair is of great research interest. Even though several biomaterials were identified as wound healing agents, gel-based scaffolds derived from either polymer or small molecules have displayed promising wound closure mechanism. Herein, for the first time, we report an injectable and self-healing self-assembled anesthetic oleogel derived from glycolipid, which exhibits antibiofilm and wound closure performance in diabetic rat. Glycolipid derived by the reaction of hydrophobic vinyl ester with α-chloralose in the presence of novozyme 435 undergoes spontaneous self-assembly in paraffin oil furnished an oleogel displaying self-healing behavior. In addition, we have prepared composite gel by encapsulating curcumin in the 3D fibrous network of oleogel. More interestingly, glycolipid in its native form demoed potential in disassembling methicillin-resistant Staphylococcus aureus, methicillin-susceptible Staphylococcus aureus, and Pseudomonas aeruginosa biofilms. Both oleogel and composite gel enhanced the wound skin repair in diabetic induced Wistar rats by promoting collagen synthesis, controlling free radical generation and further regulating tissue remodeling phases. Altogether, the reported supramolecular self-assembled anesthetic glycolipid could be potentially used for diabetic skin wound repair and to treat bacterial biofilm related infections.
- Subjects :
- Anesthetics pharmacology
Animals
Biofilms drug effects
Biofilms growth & development
Female
Methicillin-Resistant Staphylococcus aureus isolation & purification
Organic Chemicals administration & dosage
Organic Chemicals pharmacology
Rats
Rats, Wistar
Skin Diseases etiology
Skin Diseases pathology
Staphylococcal Infections microbiology
Wound Infection etiology
Wound Infection pathology
Diabetes Mellitus, Experimental physiopathology
Glycolipids pharmacology
Skin Diseases drug therapy
Staphylococcal Infections complications
Wound Healing drug effects
Wound Infection drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33093507
- Full Text :
- https://doi.org/10.1038/s41598-020-73708-7