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Comorbid posttraumatic stress disorder and major depressive disorder are associated with asthma morbidity among World Trade Center workers.
- Source :
-
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2021 Mar; Vol. 126 (3), pp. 278-283. Date of Electronic Publication: 2020 Oct 22. - Publication Year :
- 2021
-
Abstract
- Background: World Trade Center (WTC) rescue and recovery workers have a high burden of asthma, comorbid posttraumatic stress disorder (PTSD), and major depressive disorder (MDD). PTSD is associated with worse asthma outcomes.<br />Objective: In this study, we evaluated whether the relationship between PTSD and asthma morbidity is modified by the presence of MDD.<br />Methods: We used data from a cohort of WTC workers with asthma. Asthma control (asthma control questionnaire), resource utilization, and quality of life (asthma quality of life questionnaire) were evaluated. We used regression analyses to evaluate the adjusted association of PTSD and MDD with asthma control, resource utilization, and quality of life.<br />Results: Of the study cohort of 293 WTC workers with asthma, 19% had PTSD alone, 2% had MDD alone, and 12% had PTSD and MDD. Adjusted mean differences (95% confidence interval) in asthma control questionnaire scores were 1.32 (0.85-1.80) for WTC workers with PTSD and MDD, 0.44 (0.03-0.84) for those with PTSD alone, and 0.50 (-0.38 to 1.38) for workers with MDD alone compared with those without MDD or PTSD. WTC workers with PTSD and MDD, PTSD alone, and MDD alone had mean (95% confidence interval) adjusted differences in asthma quality of life questionnaire scores of -1.67 (-2.22 to -1.12), -0.56 (-2.23 to -1.12), and -1.21 (-2.23 to -0.18), respectively, compared with workers without MDD or PTSD. Similar patterns were observed for acute resource utilization.<br />Conclusion: PTSD and MDD seem to have a synergistic effect that worsens asthma control and quality of life. Efforts to improve asthma outcomes in this population should address the negative impacts of these common mental health conditions.<br /> (Copyright © 2020 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Cohort Studies
Depressive Disorder, Major complications
Female
Humans
Linear Models
Male
Mental Health
Middle Aged
Morbidity
New York City epidemiology
Quality of Life
Stress Disorders, Post-Traumatic complications
Asthma epidemiology
Depressive Disorder, Major epidemiology
Rescue Work
September 11 Terrorist Attacks psychology
Stress Disorders, Post-Traumatic epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1534-4436
- Volume :
- 126
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33098982
- Full Text :
- https://doi.org/10.1016/j.anai.2020.10.007