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Development of a multiomics database for personalized prognostic forecasting in head and neck cancer: The Big Data to Decide EU Project.

Authors :
Cavalieri S
De Cecco L
Brakenhoff RH
Serafini MS
Canevari S
Rossi S
Lanfranco D
Hoebers FJP
Wesseling FWR
Keek S
Scheckenbach K
Mattavelli D
Hoffmann T
López Pérez L
Fico G
Bologna M
Nauta I
Leemans CR
Trama A
Klausch T
Berkhof JH
Tountopoulos V
Shefi R
Mainardi L
Mercalli F
Poli T
Licitra L
Source :
Head & neck [Head Neck] 2021 Feb; Vol. 43 (2), pp. 601-612. Date of Electronic Publication: 2020 Oct 27.
Publication Year :
2021

Abstract

Background: Despite advances in treatments, 30% to 50% of stage III-IV head and neck squamous cell carcinoma (HNSCC) patients relapse within 2 years after treatment. The Big Data to Decide (BD2Decide) project aimed to build a database for prognostic prediction modeling.<br />Methods: Stage III-IV HNSCC patients with locoregionally advanced HNSCC treated with curative intent (1537) were included. Whole transcriptomics and radiomics analyses were performed using pretreatment tumor samples and computed tomography/magnetic resonance imaging scans, respectively.<br />Results: The entire cohort was composed of 71% male (1097)and 29% female (440): oral cavity (429, 28%), oropharynx (624, 41%), larynx (314, 20%), and hypopharynx (170, 11%); median follow-up 50.5 months. Transcriptomics and imaging data were available for 1284 (83%) and 1239 (80%) cases, respectively; 1047 (68%) patients shared both.<br />Conclusions: This annotated database represents the HNSCC largest available repository and will enable to develop/validate a decision support system integrating multiscale data to explore through classical and machine learning models their prognostic role.<br /> (© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.)

Details

Language :
English
ISSN :
1097-0347
Volume :
43
Issue :
2
Database :
MEDLINE
Journal :
Head & neck
Publication Type :
Academic Journal
Accession number :
33107152
Full Text :
https://doi.org/10.1002/hed.26515