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Association between triglyceride glucose-body mass index and non-alcoholic fatty liver disease in the non-obese Chinese population with normal blood lipid levels: a secondary analysis based on a prospective cohort study.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2020 Oct 28; Vol. 19 (1), pp. 229. Date of Electronic Publication: 2020 Oct 28. - Publication Year :
- 2020
-
Abstract
- Background: Both triglyceride glucose-body mass index (TyG-BMI) and non-alcoholic fatty liver disease (NAFLD) are linked to insulin resistance (IR). Prospective studies linking TyG-BMI to NAFLD have been limited by short follow-up. This study investigated the longitudinal association between TyG-BMI and NAFLD occurrence in the non-obese Chinese individuals.<br />Methods: This study determined TyG-BMI at baseline and the incidence of NAFLD at follow-up and performed a post hoc analysis of a prospective cohort study that involved assessing the risk of NAFLD in non-obese Chinese residents from January 2010 to December 2014. The incidence of NAFLD during the 5-year follow-up was identified as the endpoint. Cox proportional hazards regression analysis was used to evaluate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the incidence of NAFLD. Receiver operating characteristic (ROC) curve analysis was conducted to estimate the predictive power of TyG-BMI and its components for NAFLD. Subgroup analysis was performed to better understand other factors that may affect the association between TyG-BMI and NAFLD to identify potential special populations.<br />Results: During the follow-up period, 841 (8.61%) of 9767 non-obese subjects who met the screening criteria were diagnosed with NAFLD. After confounding factors were fully adjusted for, the HR of NAFLD was 3.09 (95% CI 2.63-3.63) per standard deviation (SD) increase in TyG-BMI. Furthermore, TyG-BMI had a strong predictive value (area under ROC = 0.85; 95% CI 0.84-0.86) for the incidence of NAFLD, with a specificity of 0.73 and sensitivity of 0.82. Additionally, in the male population, each SD increase in TyG-BMI was linked to an increased risk of NAFLD (HR = 2.85, 95% CI 2.30-3.53), but the risk was higher in the female population (HR = 3.58, 95% CI 2.80-4.60). Gender and TyG-BMI interacted significantly with NAFLD incidence (P < 0.0001).<br />Conclusion: In the normolipidaemic and non-obese subset of the Chinese population, an increase in TyG-BMI is related to an increased incidence of NAFLD. TyG-BMI may have clinical significance in identifying groups at high risk of NAFLD.
- Subjects :
- Adult
Asian People
China epidemiology
Female
Humans
Incidence
Lipids blood
Longitudinal Studies
Male
Middle Aged
Non-alcoholic Fatty Liver Disease etiology
Obesity
Prospective Studies
Risk Factors
Blood Glucose analysis
Body Mass Index
Non-alcoholic Fatty Liver Disease epidemiology
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 33109219
- Full Text :
- https://doi.org/10.1186/s12944-020-01409-1