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Antibacterial Cyclic Tripeptides from Antarctica-Sponge-Derived Fungus Aspergillus insulicola HDN151418.
- Source :
-
Marine drugs [Mar Drugs] 2020 Oct 26; Vol. 18 (11). Date of Electronic Publication: 2020 Oct 26. - Publication Year :
- 2020
-
Abstract
- Three new aspochracin-type cyclic tripeptides, sclerotiotides M-O ( 1 - 3 ), together with three known analogues, sclerotiotide L ( 4 ), sclerotiotide F ( 5 ), and sclerotiotide B ( 6 ), were obtained from the ethyl acetate extract of the fungus Aspergillus insulicola HDN151418, which was isolated from an unidentified Antarctica sponge. Spectroscopic and chemical approaches were used to elucidate their structures. The absolute configuration of the side chain in compound 4 was elucidated for the first time. Compounds 1 and 2 showed broad antimicrobial activity against a panel of pathogenic strains, including Bacillus cereus , Proteus species , Mycobacterium phlei , Bacillus subtilis , Vibrio parahemolyticus , Edwardsiella tarda , MRCNS, and MRSA, with MIC values ranging from 1.56 to 25.0 µM.
- Subjects :
- Animals
Antarctic Regions
Anti-Bacterial Agents chemistry
Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Survival drug effects
Humans
Peptides chemistry
Protein Conformation
Anti-Bacterial Agents pharmacology
Antineoplastic Agents pharmacology
Aspergillus metabolism
Bacteria drug effects
Peptides pharmacology
Porifera microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 18
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 33114712
- Full Text :
- https://doi.org/10.3390/md18110532