Back to Search Start Over

Theoretical study of industrial scale closed-loop recycling counter-current chromatography separations.

Authors :
Kostanyan AE
Belova VV
Source :
Journal of chromatography. A [J Chromatogr A] 2020 Dec 06; Vol. 1633, pp. 461630. Date of Electronic Publication: 2020 Oct 17.
Publication Year :
2020

Abstract

Industrial separation technologies can be improved and greatly simplified by using the methods of counter-current chromatography (CCC). We have previously proposed the use of currently available solvent extraction equipment (a series of multistage columns, a cascade of centrifugal mixer-settler extractors) as large-scale CCC devices. For industrial separations, the application of closed-loop recycling counter-current chromatography (CLR CCC) methods seems to be the most promising. To improve the performance of the CLR CCC separations, semi-continuous three-stage processes (1 - continuous loading of the mixture solution over a definite time; 2 - separation of solutes in recycling closed-loop; 3 - elution of the fractions of the separated solutes with the mobile phase) can be used. The purpose of this study is to present a simple and easy to use mathematical model allowing the simulation and design of various options for implementing such separation processes and analyze the influence of its main parameters on separation efficiency.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020. Published by Elsevier B.V.)

Details

Language :
English
ISSN :
1873-3778
Volume :
1633
Database :
MEDLINE
Journal :
Journal of chromatography. A
Publication Type :
Academic Journal
Accession number :
33128971
Full Text :
https://doi.org/10.1016/j.chroma.2020.461630