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Complement-mediated kidney diseases.
- Source :
-
Molecular immunology [Mol Immunol] 2020 Dec; Vol. 128, pp. 175-187. Date of Electronic Publication: 2020 Nov 01. - Publication Year :
- 2020
-
Abstract
- It has long been known that the complement cascade is activated in various forms of glomerulonephritis. In many of these diseases, immune-complexes deposit in the glomeruli and activate the classical pathway. Researchers have also identified additional mechanisms by which complement is activated in the kidney, including diseases in which the alternative and lectin pathways are activated. The kidney appears to be particularly susceptible to activation of the alternative pathway, and this pathway has been implicated as a primary driver of atypical hemolytic uremic syndrome, C3 glomerulopathy, anti-neutrophil cytoplasmic antibody-associated vasculitis, as well as some forms of immune-complex glomerulonephritis. In this paper we review the shared and distinct mechanisms by which complement is activated in these different diseases. We also review the opportunities for using therapeutic complement inhibitors to treat kidney diseases.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis immunology
Antigen-Antibody Complex immunology
Atypical Hemolytic Uremic Syndrome immunology
Complement Activation immunology
Complement Inactivating Agents immunology
Glomerulonephritis immunology
Humans
Kidney immunology
Complement System Proteins immunology
Kidney Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 128
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33137606
- Full Text :
- https://doi.org/10.1016/j.molimm.2020.10.015