A new flavanone derivative from the rhizomes of Boesenbergia pandurata .

From the methanolic extract of the rhizomes of Boesenbergia pandurata , a new flavanone derivative named (2 R ,7″ S )-8-(1-phenyl-2-carboxyethyl)pinocembrin ( 1 ) and four known flavonoids ( 2 - 5 ) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC ₅₀ value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC ₅₀ , 0.83 µM).