Back to Search
Start Over
Characteristics of Brazilian clinical studies registered in ClinicalTrials.gov between 2010 and 2020.
- Source :
-
Journal of evidence-based medicine [J Evid Based Med] 2020 Nov; Vol. 13 (4), pp. 261-264. Date of Electronic Publication: 2020 Nov 03. - Publication Year :
- 2020
-
Abstract
- Aim: Evidence-based medicine uses high-quality methods, such as randomization and blinding prcedures, to support and inform clinical practice. The investigation of trials registered in clinical research databases may help understand the main characteristics of studies conducted in countries, such as Brazil. This study aimed to investigate the characteristics of Brazilian clinical trials registered in ClinicalTrials.gov in the last decade.<br />Methods: Cross-sectional study performed in ClinicalTrials.gov database with clinical studies registered in Brazil between 2010 and 2020. A search was conducted in the database considering this period using filters for country (Brazil), start date (01 January 2010) and end date (date of the search: 07 May 2020). Descriptive statistics were used to characterize the studies. All analyses were conducted on Stata 14.2.<br />Results: In total, 5368 studies were retrieved, which were mostly randomized (93.2%), blinded (63.2%), Phase III (48.7%) interventional studies (89.9%) with small sample sizes (57.2%) conducted with adults (93.0%) using drugs (42.7%) with a treatment purpose (77.3%), with funding from institutions other than the industry, the NIH, and the US Federal (71.3%).<br />Conclusions: The majority of Brazilian clinical studies used blinding and randomization procedures in the last 10 years. However, the predominance of trials with small sample sizes and with a focus on adult patients indicate the need of larger studies conducted with the pediatric population.<br /> (© 2020 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adult
Aged
Brazil
Child
Clinical Trials as Topic methods
Clinical Trials, Phase III as Topic statistics & numerical data
Cross-Sectional Studies
Double-Blind Method
Humans
Randomized Controlled Trials as Topic methods
Randomized Controlled Trials as Topic statistics & numerical data
Single-Blind Method
Clinical Trials as Topic statistics & numerical data
Registries statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1756-5391
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of evidence-based medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33145995
- Full Text :
- https://doi.org/10.1111/jebm.12415