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Vimentin protects differentiating stem cells from stress.

Authors :
Pattabiraman S
Azad GK
Amen T
Brielle S
Park JE
Sze SK
Meshorer E
Kaganovich D
Source :
Scientific reports [Sci Rep] 2020 Nov 11; Vol. 10 (1), pp. 19525. Date of Electronic Publication: 2020 Nov 11.
Publication Year :
2020

Abstract

Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by recruiting aggregates, stress granules, and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress response.

Details

Language :
English
ISSN :
2045-2322
Volume :
10
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
33177544
Full Text :
https://doi.org/10.1038/s41598-020-76076-4