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Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands.
- Source :
-
Nature communications [Nat Commun] 2020 Nov 12; Vol. 11 (1), pp. 5744. Date of Electronic Publication: 2020 Nov 12. - Publication Year :
- 2020
-
Abstract
- The world is combating an ongoing COVID-19 pandemic with health-care systems, society and economies impacted in an unprecedented way. It is unclear how many people have contracted the causative coronavirus (SARS-CoV-2) unknowingly and are asymptomatic. Therefore, reported COVID-19 cases do not reflect the true scale of outbreak. Here we present the prevalence and distribution of antibodies to SARS-CoV-2 in a healthy adult population of the Netherlands, which is a highly affected country, using a high-performance immunoassay. Our results indicate that one month into the outbreak (i) the seroprevalence in the Netherlands was 2.7% with substantial regional variation, (ii) the hardest-hit areas showed a seroprevalence of up to 9.5%, (iii) the seroprevalence was sex-independent throughout age groups (18-72 years), and (iv) antibodies were significantly more often present in younger people (18-30 years). Our study provides vital information on the extent of exposure to SARS-CoV-2 in a country where social distancing is in place.
- Subjects :
- Adolescent
Adult
Aged
Asymptomatic Diseases epidemiology
Betacoronavirus isolation & purification
COVID-19
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Middle Aged
Netherlands
Pandemics
Prevalence
SARS-CoV-2
Seroepidemiologic Studies
Social Isolation
Young Adult
Antibodies, Viral blood
Blood Donors statistics & numerical data
Coronavirus Infections epidemiology
Pneumonia, Viral epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 33184284
- Full Text :
- https://doi.org/10.1038/s41467-020-19481-7