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Frontiers in cancer immunotherapy-a symposium report.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Apr; Vol. 1489 (1), pp. 30-47. Date of Electronic Publication: 2020 Nov 13. - Publication Year :
- 2021
-
Abstract
- Cancer immunotherapy has dramatically changed the approach to cancer treatment. The aim of targeting the immune system to recognize and destroy cancer cells has afforded many patients the prospect of achieving deep, long-term remission and potential cures. However, many challenges remain for achieving the goal of effective immunotherapy for all cancer patients. Checkpoint inhibitors have been able to achieve long-term responses in a minority of patients, yet improving response rates with combination therapies increases the possibility of toxicity. Chimeric antigen receptor T cells have demonstrated high response rates in hematological cancers, although most patients experience relapse. In addition, some cancers are notoriously immunologically "cold" and typically are not effective targets for immunotherapy. Overcoming these obstacles will require new strategies to improve upon the efficacy of current agents, identify biomarkers to select appropriate therapies, and discover new modalities to expand the accessibility of immunotherapy to additional tumor types and patient populations.<br /> (© 2020 New York Academy of Sciences.)
- Subjects :
- Biomarkers, Tumor genetics
Cancer Vaccines immunology
Cancer Vaccines therapeutic use
Combined Modality Therapy
Humans
Immune Checkpoint Inhibitors therapeutic use
Neoplasm Recurrence, Local immunology
Neoplasms genetics
Neoplasms immunology
Neoplasms pathology
Tumor Microenvironment immunology
Immunotherapy trends
Immunotherapy, Adoptive
Neoplasm Recurrence, Local therapy
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1489
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33184911
- Full Text :
- https://doi.org/10.1111/nyas.14526