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Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.
- Source :
-
The New England journal of medicine [N Engl J Med] 2021 Jan 14; Vol. 384 (2), pp. 105-116. Date of Electronic Publication: 2020 Nov 13. - Publication Year :
- 2021
-
Abstract
- Background: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown.<br />Methods: We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes.<br />Results: During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups.<br />Conclusions: Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016-002299-28.).<br /> (Copyright © 2020 Massachusetts Medical Society.)
- Subjects :
- Aged
Aged, 80 and over
Cardiac Myosins drug effects
Cardiotonic Agents adverse effects
Cardiotonic Agents pharmacology
Cardiovascular Diseases mortality
Female
Heart Failure, Systolic metabolism
Heart Failure, Systolic physiopathology
Humans
Male
Middle Aged
Myocardial Contraction drug effects
Stroke Volume
Urea adverse effects
Urea pharmacology
Urea therapeutic use
Cardiac Myosins metabolism
Cardiotonic Agents therapeutic use
Heart Failure, Systolic drug therapy
Urea analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1533-4406
- Volume :
- 384
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The New England journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33185990
- Full Text :
- https://doi.org/10.1056/NEJMoa2025797