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COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS combined cohort study.
- Source :
-
HIV research & clinical practice [HIV Res Clin Pract] 2020 Oct; Vol. 21 (5), pp. 130-139. Date of Electronic Publication: 2020 Nov 19. - Publication Year :
- 2020
-
Abstract
- Background: SARS-CoV-2 infection among People Living With HIV (PLWH) is not well-described.<br />Objective: To study COVID-19 symptoms and SARS-CoV-2 PCR-based swab testing among participants of the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS).<br />Methods: A telephone survey was collected April-June 30, 2020. Symptom and testing prevalence were explored. Multivariable logistic regression was used to examine the factors associated with SARS-CoV-2 positivity.<br />Results: The survey was completed by 3411 participants, including 2078 (61%) PLWH and 1333 HIV-seronegative (SN) participants from across the US. Thirteen percent (n = 441) were tested for SARS-CoV-2 infection (13.4% of PLWH vs 12.2% of SN). Among those tested, positivity was higher in PLWH than SN (11.2% vs 6.1%, p = 0.08). Reasons for not being tested included testing not being available (30% of participants) and not knowing where to get tested (16% of participants). Most symptoms reported since January 2020 were similar in PLWH and SN, including headache (23% vs. 24%), myalgias (19% vs 18%), shortness of breath (14% vs 13%), chills (12% vs 10%), fever (6% vs 6%) and loss of taste or smell (6% vs 7%). Among PLWH who tested positive for SARS-CoV-2 DNA, the most common symptoms were headache (71%), myalgia (68%), cough (68%) and chills (65%). In multivariable analysis among those tested, the odds of SARS-CoV-2 positivity were higher among PLWH than SN (aOR = 2.22 95%CI = 01.01-4.85, p = 0.046) and among those living with others versus living alone (aOR = 2.95 95%CI = 1.18-7.40).<br />Conclusion: Prevalence and type of COVID-19 symptoms were similar in PLWH and SN. SARS-CoV-2 infection may be elevated among PLWH.
- Subjects :
- Acquired Immunodeficiency Syndrome epidemiology
Adult
Aged
Aged, 80 and over
Ageusia epidemiology
Ageusia virology
Anosmia epidemiology
Anosmia virology
COVID-19 epidemiology
Chills epidemiology
Chills virology
Coinfection
Cough epidemiology
Cough virology
Dyspnea epidemiology
Dyspnea virology
Female
Fever epidemiology
Fever virology
HIV Infections epidemiology
Headache epidemiology
Humans
Middle Aged
Prevalence
SARS-CoV-2 isolation & purification
United States epidemiology
COVID-19 physiopathology
COVID-19 virology
HIV Infections physiopathology
HIV Infections virology
Subjects
Details
- Language :
- English
- ISSN :
- 2578-7470
- Volume :
- 21
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- HIV research & clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 33211636
- Full Text :
- https://doi.org/10.1080/25787489.2020.1844521