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Glucosamine/Chondroitin and Mortality in a US NHANES Cohort.
- Source :
-
Journal of the American Board of Family Medicine : JABFM [J Am Board Fam Med] 2020 Nov-Dec; Vol. 33 (6), pp. 842-847. - Publication Year :
- 2020
-
Abstract
- Background: Limited previous studies in the United Kingdom or a single US state have demonstrated an association between intake of glucosamine/chondroitin and mortality. This study sought to investigate the association between regular consumption of glucosamine/chondroitin and overall and cardiovascular (CVD) mortality in a national sample of US adults.<br />Methods: Combined data from 16,686 participants in National Health and Nutrition Examination Survey 1999 to 2010, merged with the 2015 Public-use Linked Mortality File. Cox proportional hazards models were conducted for both CVD and all-cause mortality.<br />Results: In the study sample, there were 658 (3.94%) participants who had been taking glucosamine/chondroitin for a year or longer. During followup (median, 107 months), there were 3366 total deaths (20.17%); 674 (20.02%) were due to CVD. Respondents taking glucosamine/chondroitin were less likely to have CVD mortality (hazard ratio [HR] = 0.51; 95% CI, 0.28-0.92). After controlling for age, use was associated with a 39% reduction in all-cause (HR = 0.61; 95% CI, 0.49-0.77) and 65% reduction (HR = 0.35; 95% CI, 0.20-0.61) in CVD mortality. Multivariable-adjusted HR showed that the association was maintained after adjustment for age, sex, race, education, smoking status, and physical activity (all-cause mortality, HR = 0.73; 95% CI, 0.57-0.93; CVD mortality, HR = 0.42; 95% CI, 0.23-0.75).<br />Conclusions: Regular intake of glucosamine/chondroitin is associated with lower all-cause and CVD mortality in a national US cohort and the findings are consistent with previous studies in other populations. Prospective studies to confirm the link may be warranted.<br />Competing Interests: Conflict of interest: None.<br /> (© Copyright 2020 by the American Board of Family Medicine.)
Details
- Language :
- English
- ISSN :
- 1558-7118
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the American Board of Family Medicine : JABFM
- Publication Type :
- Academic Journal
- Accession number :
- 33219063
- Full Text :
- https://doi.org/10.3122/jabfm.2020.06.200110