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Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data.
- Source :
-
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D1251-D1258. - Publication Year :
- 2021
-
Abstract
- An updated Lnc2Cancer 3.0 (http://www.bio-bigdata.net/lnc2cancer or http://bio-bigdata.hrbmu.edu.cn/lnc2cancer) database, which includes comprehensive data on experimentally supported long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) associated with human cancers. In addition, web tools for analyzing lncRNA expression by high-throughput RNA sequencing (RNA-seq) and single-cell RNA-seq (scRNA-seq) are described. Lnc2Cancer 3.0 was updated with several new features, including (i) Increased cancer-associated lncRNA entries over the previous version. The current release includes 9254 lncRNA-cancer associations, with 2659 lncRNAs and 216 cancer subtypes. (ii) Newly adding 1049 experimentally supported circRNA-cancer associations, with 743 circRNAs and 70 cancer subtypes. (iii) Experimentally supported regulatory mechanisms of cancer-related lncRNAs and circRNAs, involving microRNAs, transcription factors (TF), genetic variants, methylation and enhancers were included. (iv) Appending experimentally supported biological functions of cancer-related lncRNAs and circRNAs including cell growth, apoptosis, autophagy, epithelial mesenchymal transformation (EMT), immunity and coding ability. (v) Experimentally supported clinical relevance of cancer-related lncRNAs and circRNAs in metastasis, recurrence, circulation, drug resistance, and prognosis was included. Additionally, two flexible online tools, including RNA-seq and scRNA-seq web tools, were developed to enable fast and customizable analysis and visualization of lncRNAs in cancers. Lnc2Cancer 3.0 is a valuable resource for elucidating the associations between lncRNA, circRNA and cancer.<br /> (© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.)
- Subjects :
- Apoptosis genetics
Autophagy genetics
DNA Methylation
Drug Resistance, Neoplasm genetics
Enhancer Elements, Genetic
Epithelial-Mesenchymal Transition genetics
High-Throughput Nucleotide Sequencing
Humans
Internet
MicroRNAs classification
MicroRNAs genetics
MicroRNAs metabolism
Mutation
Neoplasms classification
Neoplasms drug therapy
RNA, Circular classification
RNA, Circular metabolism
RNA, Long Noncoding classification
RNA, Long Noncoding metabolism
RNA, Neoplasm classification
RNA, Neoplasm metabolism
Recurrence
Single-Cell Analysis
Software
Transcription Factors classification
Transcription Factors genetics
Transcription Factors metabolism
Databases, Genetic
Genome, Human
Neoplasms genetics
RNA, Circular genetics
RNA, Long Noncoding genetics
RNA, Neoplasm genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1362-4962
- Volume :
- 49
- Issue :
- D1
- Database :
- MEDLINE
- Journal :
- Nucleic acids research
- Publication Type :
- Academic Journal
- Accession number :
- 33219685
- Full Text :
- https://doi.org/10.1093/nar/gkaa1006