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Epidemiology and biology of a herpesvirus in rabies endemic vampire bat populations.
- Source :
-
Nature communications [Nat Commun] 2020 Nov 23; Vol. 11 (1), pp. 5951. Date of Electronic Publication: 2020 Nov 23. - Publication Year :
- 2020
-
Abstract
- Rabies is a viral zoonosis transmitted by vampire bats across Latin America. Substantial public health and agricultural burdens remain, despite decades of bats culls and livestock vaccinations. Virally vectored vaccines that spread autonomously through bat populations are a theoretically appealing solution to managing rabies in its reservoir host. We investigate the biological and epidemiological suitability of a vampire bat betaherpesvirus (DrBHV) to act as a vaccine vector. In 25 sites across Peru with serological and/or molecular evidence of rabies circulation, DrBHV infects 80-100% of bats, suggesting potential for high population-level vaccine coverage. Phylogenetic analysis reveals host specificity within neotropical bats, limiting risks to non-target species. Finally, deep sequencing illustrates DrBHV super-infections in individual bats, implying that DrBHV-vectored vaccines might invade despite the highly prevalent wild-type virus. These results indicate DrBHV as a promising candidate vector for a transmissible rabies vaccine, and provide a framework to discover and evaluate candidate viral vectors for vaccines against bat-borne zoonoses.
- Subjects :
- Animals
Betaherpesvirinae classification
Betaherpesvirinae genetics
Biological Coevolution
Cattle
Chiroptera classification
Genome, Viral genetics
Herpesviridae Infections epidemiology
Herpesviridae Infections veterinary
Herpesviridae Infections virology
Host Specificity
Mammals classification
Mammals virology
Peru epidemiology
Phylogeny
Rabies prevention & control
Rabies transmission
Rabies virus immunology
Rabies virus physiology
Seroepidemiologic Studies
Superinfection veterinary
Superinfection virology
Betaherpesvirinae physiology
Chiroptera virology
Rabies epidemiology
Rabies veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 33230120
- Full Text :
- https://doi.org/10.1038/s41467-020-19832-4