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White matter hyperintensities at critical crossroads for executive function and verbal abilities in small vessel disease.
- Source :
-
Human brain mapping [Hum Brain Mapp] 2021 Mar; Vol. 42 (4), pp. 993-1002. Date of Electronic Publication: 2020 Nov 24. - Publication Year :
- 2021
-
Abstract
- The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH. We used Stroop Word Reading, Stroop Color Naming, Stroop Color-Word Naming, and Category Fluency as language measures with varying degrees of executive demands. The Symbol Digit Modalities Test (SDMT) was used as a control task, as it measures processing speed without requiring language use or verbal output. A voxel-based lesion-symptom mapping (VLSM) approach was used, corrected for age, sex, education, and lesion volume. VLSM analyses revealed statistically significant clusters for tests requiring language use, but not for SDMT. Worse scores on all tests were associated with WMH in forceps minor, thalamic radiations and caudate nuclei. In conclusion, an association was found between WMH in a core frontostriatal network and executive-verbal abilities in SVD, independent of lesion volume and processing speed. This circuitry underlying executive-language functioning might be of potential clinical importance for elderly with SVD. More detailed language testing is required in future research to elucidate the nature of language production difficulties in SVD.<br /> (© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
- Subjects :
- Aged
Aged, 80 and over
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Caudate Nucleus diagnostic imaging
Caudate Nucleus pathology
Caudate Nucleus physiopathology
Cerebral Small Vessel Diseases diagnostic imaging
Cerebral Small Vessel Diseases pathology
Cerebral Small Vessel Diseases physiopathology
Executive Function physiology
Nerve Net diagnostic imaging
Nerve Net pathology
Nerve Net physiopathology
Prefrontal Cortex diagnostic imaging
Prefrontal Cortex pathology
Prefrontal Cortex physiopathology
Psycholinguistics
White Matter diagnostic imaging
White Matter pathology
White Matter physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0193
- Volume :
- 42
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Human brain mapping
- Publication Type :
- Academic Journal
- Accession number :
- 33231360
- Full Text :
- https://doi.org/10.1002/hbm.25273