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Artemisia biennis Willd.: Anti-Nociceptive effects and possible mechanisms of action.

Artemisia biennis Willd.: Anti-Nociceptive effects and possible mechanisms of action.

Authors :
Zarei M
Ahmadimoghaddam D
Mohammadi S
Source :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113604. Date of Electronic Publication: 2020 Nov 21.
Publication Year :
2021

Abstract

Ethnopharmacological Relevance: Artemisia biennis Willd. (Dermane in Persian) has been used as an antinociceptive remedy in Iranian folkloric medicine.<br />Objective: The aim of the present study was to evaluate the anti-nociceptive effects of Artemisia biennis Willd. aerial part essential oil (ABAEO) on male Swiss mice.<br />Materials and Methods: Nociceptive pain techniques including acetic acid-induced writhing (AAIW), formalin-induced paw licking (FPL), glutamate-induced paw licking (GPL), and tail-flick (TF) models were applied. We assessed opioid and L-arginine-NO-cGMP-KATP pathways to detect the possible anti-nociceptive properties of ABAEO. In addition, neuropathic pain was induced by the cervical spinal cord contusion model.<br />Results: ABAEO (120 mg/kg) had a significant anti-nociceptive activities in comparison to the control animals (p < 0.05) in the AAIW, TF, GPL, and FPL assays. The selective opioid antagonist (naloxonazine) administration in the AAIW test alleviated the anti-nociceptive effect of ABAEO (p < 0.05). L-arginine, methylene blue, and glibenclamide treatment prevented the ABAEO anti-nociceptive effects (p < 0.05); however, sodium nitroprusside could profoundly potentiate the ABAEO-associated antinociception in the FPL (phase II) test (p < 0.05). In nociceptive pain models, Cr (one of the main constituents of ABAEO) showed significant anti-nociceptive effects (p < 0.05). Moreover, the von Frey results indicated that ABAEO could attenuate mechanical allodynia in mice.<br />Conclusion: Our observation revealed the anti-nociceptive effects of ABAEO in male mice. These effects could include, at least in part, modulating glutamatergic mechanisms via opioid systems. Our data output also indicates activating the L-arginine-NO-cGMP-KATP system in ABAEO anti-nociceptive activities.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-7573
Volume :
268
Database :
MEDLINE
Journal :
Journal of ethnopharmacology
Publication Type :
Academic Journal
Accession number :
33232780
Full Text :
https://doi.org/10.1016/j.jep.2020.113604