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Establishment of an African green monkey model for COVID-19 and protection against re-infection.
- Source :
-
Nature immunology [Nat Immunol] 2021 Jan; Vol. 22 (1), pp. 86-98. Date of Electronic Publication: 2020 Nov 24. - Publication Year :
- 2021
-
Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments. We show that African green monkeys (AGMs) support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species. SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days after exposure. Marked inflammation and coagulopathy in blood and tissues were prominent features. Transcriptome analysis demonstrated stimulation of interferon and interleukin-6 pathways in bronchoalveolar lavage samples and repression of natural killer cell- and T cell-associated transcripts in peripheral blood. Despite a slight waning in antibody titers after primary challenge, enhanced antibody and cellular responses contributed to rapid clearance after re-challenge with an identical strain. These data support the utility of AGM for studying COVID-19 pathogenesis and testing medical countermeasures.
- Subjects :
- Animals
Antibodies, Viral immunology
COVID-19 epidemiology
COVID-19 virology
Chlorocebus aethiops
Epidemics prevention & control
Gene Expression genetics
Gene Expression immunology
Gene Expression Profiling
Humans
Interferons genetics
Interferons immunology
Interferons metabolism
Killer Cells, Natural immunology
Killer Cells, Natural metabolism
Reinfection virology
SARS-CoV-2 physiology
T-Lymphocytes metabolism
T-Lymphocytes virology
COVID-19 immunology
Disease Models, Animal
Reinfection immunology
SARS-CoV-2 immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33235385
- Full Text :
- https://doi.org/10.1038/s41590-020-00835-8